Proceedings of 2018 ASEE Northeast Section Conference

Glucose Concentration Simulation for Closed-Loop Treatment in Type 1 Diabetes
Marilyn Urrea, Nora Richardson, Joseph Martel-Foley, Douglas E Dow

People with Type 1 diabetes do not produce sufficient insulin that would regulate the increases in blood glucose following food intake. Currently many diabetic patients use blood glucose monitors and knowledge of what food they have eaten to administer appropriate doses of insulin. The insulin injections may be done manually or with an automated pump device. A closed-loop control system based on automatic monitoring of blood glucose levels and automatic administration of insulin would ease the burden of self-observation and treatment for many people. However, difficulties and reliability have limited wide-spread clinical application. The purpose of this project was to develop a simulation of blood glucose concentration in the body based on food intake, rates of digestion, rates of glucose concentration, and insulin-controlled storage of excess blood glucose into body stores. The simulation was developed in LabView. The program simulates the net flow of glucose into and out of the blood. Food intake is selected and converted into glycemic load as it enters the digestive system. Then glucose is gradually digested and enters the blood system, which increases the blood glucose concentration. Consumption of glucose by body tissue decreases the blood glucose concentration. Based on insulin concentration in the blood, excessive blood glucose can be moved to body stores, such as liver, fats and muscle. This simulation should be useful toward development of closed-loop control systems for diabetes management.

Last modified: 2018-04-29
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