Abstract - Diabetes has become a serious global health threat and glucose test is very important for diabetic patients on a daily basis. Traditional blood glucose test uses a lancet device to prick the patient’s finger to get a drop of blood sample for testing. This invasive test causes pain to patient and increases the risk of cross-infection of blood-transmitted diseases. Non-invasive glucose monitoring has become very attractive alternative to blood glucose test. Research has found that other biological samples (e.g. saliva, tears, sweat, urine) also contains trace amount of glucose molecules and they may be used for diabetes diagnosis. However, glucose level in such biological samples is generally too low for traditional sensors. Nanotechnology offers new hope in high-resolution glucose sensing. In this research, we proposed a saliva glucose sensor that combines graphene-based glucose nanosensor with microfluidic biochip to develop a complete lab-on-a-chip (LoC) system for non-invasive glucose sensing. It is designed to collect, prepare and manipulate the microfluidic sample for glucose sensing using graphene-based glucose nanosensor. The key components of the lab-on-a-chip are designed and simulated with COMSOL. The LoC device may be used for non-invasive glucose sensing for diabetes diagnosis and self-monitoring.  

Corresponding Author: Peiqiao Wu, peiqiaow@my.bridgeport.edu.